张梁

日期：2017.11.14来源：暂无点击数：219

张梁，男，江西彭泽人，理学博士，硕士生导师，副教授。2004年于江西中医药大学获理学学士学位，2007年于上海中医药大学医学硕士学位，2011年于北京大学获理学博士学位，2013.11-2014.11于University of Massachusetts Amherst从事博士后(访问学者)工作，主要研究黑茶成分对于脂质吸收代谢的影响。2011.1至今任教于安徽农业大学茶与食品科技学院。任职以来，教学上主要讲授本科生的天然产物化学、食品风味化学等课程。科研上，主要从事黑茶化学成分及保健功效开发研究。目前，主持国家自然科学基金青年基金1项，安徽省自然科学基金青年基金项目1项，国家博士后基金面上基金1项；参与国家自然科学基金面上基金项目5项。近5年来在Journal of Agricultural and Food, Food Chemistry, Food Research International等期刊发表相关学术论文40余篇。

Dr Zhang graduated from Peking University in 2010, and joined the School of Food & Tea Science and Technology of Anhui Agricultural University in January 2011 as an Assistant professor (Natural Product Chemistry), and promoted to Associate professor in Jan 2015. His research expertise is in organic chemistry, bio-analytical chemistry and ADME (absorption, distribution, metabolism and excretion) of tea. He has co-authored more than 40 papers in refereed journals, including Food Chemistry, Journal of Agricultural and Food Chemistry, Food Research International. In recognition of his achievements in research, he was honored with a Young Scientist Award (China Tea Science Society). He was also the invited reviewers for RSC Advances, Food Chemistry.

　获奖：

2015年第四届中国茶叶学会青年科技奖；

　主讲课程：

《天然产物化学》，《食品营养与卫生学》

　科研项目：

2012.5    黑茶中儿茶素类代谢产物及其降脂活性研究, 中国博士后科学基金会, 已结题, 主持人
2013.3    EGCG在黑茶发酵菌种作用下的代谢途径和关键代谢产物的降脂活性, 安徽省自然科学基金, 已结题, 主持人
2012.8    构建EGCG代谢模型寻找黑茶中降脂活性成分和关键代谢菌株, 国家自然科学基金委员会, 已结题, 主持人
2011.8    茯砖茶由发花而产生的特有次生代谢产物及其抗菌活性研究,国家自然基金委, 已结题, 参与人
另外参与多项国家基金项目的研究；

　论文论著：

2016年论文
1. Tian-Qi Rui, Liang Zhang, Hong-Zhi Qiao, Ping Huang, Shuai Qian, Jun-Song Li, Zhi-Peng Chen, Ting-Ming Fu, Liu-Qing Di, Baochang Cai. Preparation and Physicochemical and Pharmacokinetic Characterization of Ginkgo Lactone Nanosuspensions for Antiplatelet Aggregation. Journal of Pharmaceutical Sciences, 2016, 105(1), 242-249.
2. Liang Zhang, Yijun Wang, Daxiang Li, Chi-Tang Ho, Junsong Li, Xiaochun Wan. The absorption, distribution, metabolism and excretion of procyanidins. Food & Function, 2016, 7, 1237-1281.

2015年论文
3.    Liang Zhang, Yuhui Han, Liwei Xu, Yuhong Liang, Xin Chen, Junsong Li, Xiaochun Wan. The effects of co-administration of butter on the absorption, metabolism and excretion of catechins in rats after oral administration of tea polyphenols. Food & Function, 2015,6(7), 2249-2256.
4.    Liang Zhang, Yuhui Han,  Jinjun Shan,  Yuhong Liang,, Liwei Xu, Shihua Zhang, Jun-Song Li, Xiaochun Wan. Simultaneous determination of seven catechins in rat plasma by ultra-high performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetics study, Analytical Methods, 2015, 7(22), 9415-9420.
5.    Liwei Xu., Yuhong Liang, Xin Chen, Bo Chen, Yuhui Han, Liang Zhang*. (2015). Hyperlipidemia affects the absorption, distribution and excretion of seven catechins of rats following oral administration of tea polyphenols. RSC Advances, 2015, 5 (119), 97988--97994.
6.    Jun-Hui Yang†, Liang Zhang† (First author), Jun-Song Li, Li-Hua Chen, Qin Zheng, Ting Chena, Zhi-Peng Chen, Ting-Ming Fu, Liu-Qing Di. Enhanced oral bioavailability and prophylactic effects on oxidative stress and hepatic damage of an oil solution containing a rosmarinic acid-phospholipid complex. Journal of Functional Food, 2015,19:63–73.
7.    Xiao-Cui Qian†, Liang Zhang† (First author), Yi Tao, Ping Huang, Jun-Song Li, Chuan Chai, Wen Li, Liu-Qing Di, Bao-Chang Cai, Simultaneous determination of ten alkaloids of crude and wine-processed Rhizoma Coptidis aqueous extracts in rat plasma by UHPLC–ESI–MS/MS and its application to a comparative pharmacokinetic study, Journal of Pharmaceutical and Biomedical Analysis, 2015,105:64-73.
8.    Zong, Jianfa., Wang, Ruilong., Bao, Guanhu., Ling, Tiejun., Zhang, Liang., Zhang, Xinfu., & Hou, Ruyan.. Novel triterpenoid saponins from residual seed cake of Camellia oleifera Abel. show anti-proliferative activity against tumor cells. Fitoterapia, 2015, 104, 7-13.
9.    张宁, 宛晓春, 周杰, 张梁*. 泾渭茯茶化学成分 HPLC 指纹图谱的研究. 西北农林科技大学学报: 自然科学版, 2015, 43(9): 103-108.

2014 年论文
10.    Liang Zhang, Wei-Wei Deng, Xiao-Chun Wan. Advantage of LC-MS metabolomics to identify marker compounds of two types of Chinese dark teas after different postfermentation processes, Food Science and Biotechnology, 2014, 23(2): 355-360.
11.    Weinan Wang†, Liang Zhang† (First author), Shu Wang, Shepo Shi, Yong Jiang, Ning Li, Pengfei Tu, 8-C N-ethyl-2-pyrrolidinone substituted flavan-3-ols as the marker compounds of Chinese dark teas formed in the post-fermentation process provide significant antioxidative activity, Food Chemistry,2014, 152(1):539-545.
12.    Ping Huang†, Liang Zhang†(First author), Chuan Chai, Xiaocui Qian, Wen Li, Jun-Song Li, Liu-Qing Di, Bao-Chang Cai, Effects of Food and Gender on the Pharmacokinetics of Ginkgolides A, B, C and Bilobalide in Rats after Oral Dosing with Ginkgo Terpene Lactones extract, Journal of Pharmaceutical and Biomedical Analysis, 2014,100:138-144.
13.    Jie Zhou†, Liang Zhang† (First author), Jingsong Zhang, Xiaochun Wan. Aqueous extract of post-fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition, BMC Complementary and Alternative Medicine 2014, 14:263-270.
14.    Lin Feng, Ming-Jun Gao, Ru-Yan Houa, Xiao-Yi Hu, Liang Zhang, Xiao-Chun Wan, Shu Wei. Determination of quality constituents in the young leaves of albino tea cultivars. Food Chemistry. 2014, 155:98-104.
15.    Jin Liang, Lin Cao, Liang Zhang, Xiao-Chun Wan. Preparation, characterization, and in vitro antitumor activity of folate conjugated chitosan coated EGCG nanoparticles. 2014, 23(2): 569-575.
16.    张梁*, 韩煜晖, 秦金花. 发酵茶叶水浸出物对PC12神经细胞保护作用. 食品研究与开发, 2014, 35(4):1-4.

2013年论文
17.    Liang Zhang, Zheng-Zhu Zhang, Yi-bin Zhou, Tie-jun Ling; Xiao-Chun Wan. Chinese dark teas: postfermentation, chemistry and biological activities, Food research international, 2013, 53(2):600-607.
18.    Ning Li, Liang Zhang, Ke-Wu Zeng, Yuan Zhou, Jia-Yu Zhang, Yan-Yun Che, Peng-Fei Tu. Cytotoxic steroidal saponins from Ophiopogon japonicas. Steroids, 2013, 78(1):1-7.
19.    张梁, 屠鹏飞. 普洱茶中黄酮类化学成分研究. 中国中药杂志, 2013, 38(9):26-29.
20.    张梁*，农林院校《天然产物化学》教学内容和方法改革探讨. 安徽农学通报, 2013, 19(05):114-116.
21.    张梁*, 周杰, 朱蔚, 张世华. HPLC-DAD-ESI-MSn和GC-MS比较陈皮橘皮和霉变橘皮中的化学成分. 食品与发酵工业, 2013, 39(4):192-199.
22.    朱圣洁, 桑八一, 张正竹, 张梁*. 绿茶糖苷类香气前体的GC-MS和HPLC-ESI-MSn分析. 天然产物研究与开发, 2013, 25(7): 922-927.
23.    张梁*, 周杰, 秦金花. 多种茶叶废料中多酚类成分和咖啡碱的含量测定. 食品科学, 2013, 34(20):113-116.
24.    盛俊, 张梁*, 张正竹. 普洱茶中咖啡碱在小鼠体内的吸收情况研究. 安徽农业大学学报, 2013,40(6):912-916.

2012年论文
25.    Liang Zhang, Zheng-Zhu Zhang, Ya-Ning Lu, Jing-Song Zhang. Intestinal transport of L-theanine from green tea and effects on human healthcares. In: Preedy, Victor. Ed. Tea in Health and Disease Prevention, Academic Press Inc, 2012, 1st Edition, 425-435.
26.    Liang Zhang, Wan-fang Shao, Li-feng Yuan, Peng-fei Tu, Zhi-zhong Ma. Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM). Food Chemistry, 2012, 135 (4): 2222–2228.
27.    Jin-Hua Qin, Ning Li, Peng-Fei Tu, Zhi-Zhong Ma, Liang Zhang*. Change in Tea Polyphenol and Purine Alkaloid Composition during Solid-State Fungal Fermentation of Postfermented Tea, Journal of Agricultural and Food Chemistry, 2012, 60 (5): 1213–1217.
28.    Che Yan-Yun, Zhang Liang, Li Ning, Zeng Ke-Wu, Tu Peng-Fei. Triterpenoid saponins from Ilex mamillata C.Y. Wu ex C.J. Tseng. Natural Product Research, 2012. 26(21):1991-1995.
29.    Xin-Fu Zhang, Ying-Ying Han, Guan-Hu Bao, Tie-Jun Ling, Liang Zhang, Li-Ping Gao, Tao Xia. A New Saponin from Tea Seed Pomace (Camellia oleifera Abel) and Its Protective Effect on PC12 Cells. Molecules. 2012, 17(10):11721-11728.
30.    Ning Li, Jia-Yu Zhang, Ke-Wu Zeng, Liang Zhang, Yan-Yun Che, Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicas, Fitoterapia, 2012, 83(6):1042-1045.
31.    吴慧, 张梁, 朱圣洁, 张正竹. 绿茶水提物中主要次生代谢产物的分离纯化与结构鉴定. 天然产物研究与开发, 2012, 12: 1750-1752.
32.    张梁*. 如何培养研究生的科研兴趣. 科技导报,  2012, 30(03): 82.

2011年论文
33.    Liang Zhang, Zhi-Zhong Ma, Yan-Yun Che, Ning Li, Peng-Fei Tu, Protective effect of a new amide compound from Pu-erh tea on human microvascular endothelial cell against cytotoxicity induced by hydrogen peroxide, Fitoterapia, 2011, 82(2), 267-271.
34.    Liang Zhang, Ning Li, Yan-Yun Che, Zhi-zhong Ma, Peng-Fei Tu. Development of the fingerprints of aged Pu-erh tea and ripened Pu-erh tea by high-performance liquid chromatography, Journal of Chinese Pharmaceutical Sciences, 2011, 20(4): 351-357.
35.    Liang Zhang, Ning Li, Zhi-Zhong Ma, Peng-Fei Tu. Comparison of the chemical constituents of aged Pu-erh tea, ripened Pu-erh tea and other teas using HPLC-DAD-ESI-MSn. Journal of Agricultural and Food Chemistry, 2011, 59 (16): 8754–8760.
36.    CHE Yan-Yun, LI Ning, Zhang Liang, TU Peng-Fei, Triterpenoid Saponins from the Leaves of Ilex kudingcha, Chinese Journal of Natural Medicines, 2011, 9(1): 22-25.
37.    Xiao-Juan Lai, Liang Zhang, Jun-Song Li, Hang-Qing Liu, Xun-Hong Liu, Liu-Qing Di, Bao-Chang Cai,  Li-Hua Chen，Comparative pharmacokinetic and bioavailability studies of three salvianolic acids after the administration of Salviae miltiorrhizae alone or with synthetical borneol in rats, Fitoterapia, 2011, 82(6):883-888.
38.    Chu Song-ling, Fu Hong, Yang Jin-xia, Liu Geng-xin, Dou Pan, Zhang Liang, Tu Peng-fei, Wang Xue-mei, A randomized double-blind placebo-controlled study of Pu’er tea extract on the regulation of metabolic syndrome. Chinese Journal of Integrative Medicine. 2011, 17(7): 492-498.

2010年以前论文
39.    张梁,  徐德生, 冯怡, 2007, 芍药甘草复方大鼠血中移行组分归属分析研究，中国中药杂志, 32(17): 1789-1791.
40.    沈岚,  张梁,  冯怡,  徐德生, 林晓, 2009,芍药甘草复方配伍药动学研究，中成药, 31(3): 374-377.
41.    沈岚,  张梁,  冯怡,  徐德生, 林晓, 2008,芍药甘草复方效应组分谱效关系研究，中国中药杂志, 33(22): 2658-2662.
42.    陈丽华, 冯怡, 徐德生, 李俊松, 张梁, 2007, 芍药甘草复方效应组分对大鼠胃底环行肌条作用的研究，中药药理与临床, 23(6): 1-4.
43.    沈岚;  冯怡;  徐德生;  林晓;  张梁, 2008, 配伍前后芍药特征化学组分体内药动学变化研究，中国药学杂志, 43(23): 1774-1776.
44.    毕丹,  宋月林,  张梁,  陈东,  屠鹏飞, 2009,鹅胆的化学成分研究，中草药, 40(10): 1543-1545.
45.    陈丽华,  冯怡,  徐德生,  李俊松,  张梁,  汪益涵, 2008,  含甘草酸效应组分微丸的制备及其性质考察，中国中药杂志, 33(5): 509-513.
46.    沈岚;  冯怡;  徐德生; 林晓; 洪燕龙;  王优杰;  张梁，2010, 基于HPLC-DAD-ESI-MS技术的芍药甘草汤体内外物质基础变化研究, 中国中药杂志, 35(15): 1947-1952.

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