张劲松

张劲松

工作经历

2009.3至今 安徽农业大学

2002.3─2009.2 中国科学技术大学

2000.3─2002.2 Institute of Food Research, UK

1999.8─2000.2 中国科学技术大学

1988.9─1999.7合肥经济技术学院

学习经历

2002.9─2004.7 固体物理研究所 博士

1985.9─1988.7 安徽农学院 硕士

1981.9─1985.7 安徽农学院 学士

荣誉

全国优秀教师

第三届中国优秀青年科技创业奖

 研究领域

        营养与毒理，涉及茶与健康、硒与健康。发明纳米硒制备方法并阐述纳米硒高安全性（中国专利ZL97107038.5；1，13，20），发明硒代硫酸钠提高顺铂抗肿瘤疗效方法（美国专利US 8,480,995 B2，中国专利ZL200710023256.4；19，28），建立硒预防肿瘤腹腔转移概念（36）。论文他引次数逾千，硒与其它食品功能成分协同作用（3）被BBC News、The Times、The Guardian报道，FDA专家邀请参编三部毒理学专著（22，25，37），Chemical Reviews等二十余种SCI期刊邀请评议论文。

(37) Zhang L, Wu S, Wang D, Wan X, Zhang J (corresponding author, *). Epigallocatechin-3-gallate (EGCG) in or on nanoparticles: Enhanced stability and bioavailability of EGCG encapsulated in nanoparticles or targeted delivery of gold nanoparticles coated with EGCG. In: Sahu SC, Casciano D (eds) Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. John Wiley & Sons, pp 131-144, 2014.

(36) Wang X, Sun K, Tan Y, Wu S, Zhang J*. Efficacy and safety of selenium nanoparticles administered intraperitoneally for the prevention of growth of cancer cells in the peritoneal cavity. Free Radic Biol Med. 72C:1-10, 2014.

(35) Sun K, Eriksson SE, Tan Y, Zhang L, Arnér ES, Zhang J*. Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury. Biochim Biophys Acta. 1840:2105-2111, 2014.

(34) Zhang L, Wei Y, Zhang J*. Novel mechanisms of anticancer activities of green tea component epigallocatechin-3-gallate. Anticancer Agents Med Chem. 14:779-786, 2014.

(33) Wu S, Sun K, Wang X, Wang D, Wan X, Zhang J*. Protonation of epigallocatechin-3-gallate (EGCG) results in massive aggregation and reduced oral bioavailability of EGCG-dispersed selenium nanoparticles. J Agric Food Chem. 61:7268-7275. 2013.

(32) Sun K, Wu S, Wang Y, Wan X, Thompson HJ, Zhang J*. High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity. Food Chem Toxicol. 52:36–41, 2013.

(31) Huang J, Zhang Y, Zhou Y, Zhang Z, Xie Z, Zhang J, Wan X. Green tea polyphenols alleviate obesity in broiler chickens through the regulation of lipid-metabolism-related genes and transcription factor expression. J Agric Food Chem. 61:8565-8572, 2013.

(30) Wang Y, Lu H, Wang D, Li S, Sun K, Wan X, Taylor EW, Zhang J*. Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase. Toxicol Appl Pharmacol. 265:342-350, 2012.

(29) Wang D, Taylor EW, Wang Y, Wan X, Zhang J*. Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention. Int J Nanomedicine. 7:1711–1721, 2012.

(28) Li J, Sun K, Ni L, Wang X, Wang D, Zhang J*. Sodium selenosulfate at an innocuous dose markedly prevents cisplatin-induced gastrointestinal toxicity. Toxicol Appl Pharmacol. 258:376-383, 2012.

(27) Zhang J*, Taylor EW, Wan X, Peng D*. Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles. Int J Nanomedicine. 7:815–825, 2012.

(26) Zhang L, Zhang Z, Lu Y, Zhang J, Preedy VR. L-theanine from green tea: Transport and effects on health. In: Preedy VR (ed) Tea in Health and Disease Prevention. Academic Press, pp 425-435, 2012.

(25) Zhang J*, Spallholz J. Toxicity of selenium compounds and nano-selenium particles. In: Casciano D, Sahu SC (eds) Handbook of Systems Toxicology. John Wiley & Sons. pp 787-802, 2011.

(24) Lu Y, Zhang J, Wan X, Long M, Li D, Lei P, Zhang Z. Intestinal transport of pure theanine and theanine in green tea extract: Green tea components inhibit theanine absorption and promote theanine excretion. Food Chem. 125:277-280, 2011.

(23) Li S, Zhang J*, Li J, Chen D, Matteucci M, Curd J, Duan J. Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302. Biol Trace Elem Res. 136:294-301, 2010.

(22) Zhang J*. Biological properties of red elemental selenium at nano size (Nano-Se) in vitro and in vivo. In: Sahu SC, Casciano D (eds) Nanotoxicity: From In Vivo and In Vitro Model to Health Risks. John Wiley & Sons. pp 97-114, 2009.

(21) Wang X, Zhang J*, Xu T. Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level. Eur J Heart Failure. 11:154-162, 2009.

(20) Zhang J*, Wang X, Xu T. Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice. Toxicol Sci. 101:22-31, 2008.

(19) Zhang J*, Peng D, Lu H, Liu Q. Attenuating the toxicity of cisplatin by using selenosulfate with reduced risk of selenium toxicity as compared with selenite. Toxicol Appl Pharmacol. 226:251-259, 2008.

(18) Zhang J*, Wang X, Lu H. Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase. Cancer Lett. 260:127-136, 2008.

(17) Wang X, Zhang J*, Xu T. Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy. Eur J Pharmacol. 579:66-73, 2008.

(16) Zhang J*, Wang H, Peng D, Taylor EW. Further insight into the impact of sodium selenite on selenoenzymes: High-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury. Toxicol Lett. 176:223-229, 2008.

(15) Zhang J*, Lu H, Wang X. Sodium selenosulfate synthesis and demonstration of its in vitro cytotoxic activity against HepG2, Caco2 and three kinds of leukemia cells. Biol Trace Elem Res. 125:13-21, 2008.

(14) Li H, Zhang J, Wang T, Luo W, Zhou Q, Jiang G. Elemental selenium particles at nano size (Nano-Se) are more toxic to Medaka (Oryzias latipes) as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite. Aquat Toxicol 89:251-256, 2008.

(13) Wang H, Zhang J*, Yu H. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic Biol Med. 42:1524-1533, 2007.

(12) Zhang J*, Lu H. Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity. Free Radic Biol Med. 43:1574-1583, 2007.

(11) Wang X, Zhang J*, Xu T. Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo. Toxicol Appl Pharmacol. 218:88-95, 2007.

(10) Zhang J*, Wang H, Yu H. Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation. Toxicol Appl Pharmacol. 224:81-88, 2007.

(9) Peng D, Zhang J*, Liu Q, Taylor EW. Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity. J Inorg Biochem. 101:1457-1463, 2007.

(8) Peng D, Zhang J*, Liu Q. Effect of sodium selenosulfate on restoring activities of selenium-dependent enzymes and selenium retention compared with sodium selenite in vitro and in vivo. Biol Trace Elem Res. 117:77-88, 2007.

(7) Zhang J*, Ma K, Wang H. Cyclophosphamide suppresses thioredoxin reductase in bladder tissue and its adaptive response via inductions of thioredoxin reductase and glutathione peroxidase. Chem Biol Interact. 162:24-30, 2006.

(6) Zhang J*, Wang H, Yan X, Zhang L. Comparison of short-term toxicity between Nano-Se and selenite in mice. Life Sci. 76:1099-1109, 2005.

(5) Zhang J*, Wang H, BaoY, Zhang L. Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. Life Sci. 75:237-244, 2004.

(4) Huang B, Zhang J (co-first author), Hou J, Chen C. Free radical scavenging efficiency of Nano-Se in vitro. Free Radic. Biol Med. 35:805-813, 2003.

(3) Zhang J, Svehlíková V, Bao Y, Howie AF, Beckett GJ, Williamson G. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis. 24:497-503, 2003.

(2) Gao X, Zhang J, Zhang L. Hollow sphere selenium nanoparticles: their in-vitro anti hydroxyl radical effect. Adv Mater. 14:290-293, 2002.

(1) Zhang J, Gao X, Zhang L, Bao Y. Biological effects of a nano red elemental selenium. Biofactors. 15:27-38, 2001.